Mouse Skipping
	I have also noticed odd mouse behavior. For example, if I'm flying, and I drop out of flight, my character will land with the camera facing slightly to the right of my character's actual point of view. It's very annoying, as it requires me to reset the camera position (which I've set to a handy key bind).
Sometimes, also, when placing a targeted AOE, the cursor seems to be out of synch with the targeting reticle. Highly annoying. No real idea what's causing it.
iMac
2.7Ghz Intel Core i5 
4GB 1333 MHz DDR3
AMD Radeon HD 6770M 512 MB
Mac OS X Lion 10.7.4 (11E53)
System Report:
Hardware Overview:
  Model Name:	iMac
  Model Identifier:	iMac12,2
  Processor Name:	Intel Core i5
  Processor Speed:	2.7 GHz
  Number of Processors:	1
  Total Number of Cores:	4
  L2 Cache (per Core):	256 KB
  L3 Cache:	6 MB
  Memory:	4 GB
  Boot ROM Version:	IM121.0047.B1E
  SMC Version (system):	1.72f2
  Serial Number (system):	C02H20LJDHJP
  Hardware UUID:	E09F6BBF-9397-5403-A2C9-A66BC4BA6EEC
USB Device Tree:
Microsoft® 2.4GHz Transceiver v7.0:
  Product ID:	0x0745
  Vendor ID:	0x045e  (Microsoft Corporation)
  Version:	6.33
  Speed:	Up to 12 Mb/sec
  Manufacturer:	Microsoft
  Location ID:	0xfa130000 / 6
  Current Available (mA):	500
  Current Required (mA):	100
        
Only things I can think of are don't use the mouse's own software or 3rd party software (let the Apple drivers work) and make sure CoH is set to a native display resolution for the Mac instead of scaling.
Manga @ Triumph
"Meanwhile In The Halls Of Titan"...Titan Network Working To Save City Of Heroes
Save Paragon City! Efforts Coordination
	I've had a similar issue since the day I started playing the game, though where I usually see it is when I'm running or flying (I use "W" to move forward and use my mouse to steer), and my character will abruptly veer to the right as if I had jerked the mouse in that direction. Usually it's not a big issue, though occasionally it's resulted in my character running right into a crowd of enemies, which can sometimes mean trouble if that character is a blaster.
As CuppaManga suggests, this may be related to my using a Logitech wireless mouse with its own software.
        
	I've recently learned that the odd behavior with the mouse is NOT limited to the Mac version of COH. I have several machines with COH installed on them, and I can reproduce the behavior on clients running Win7 64 bit.
 
It's definitely not Mac-specific. It's something with COH.
        
I use a Microsoft Wireless Mobile Mouse with my macbook and when I play the game the pointer jumps around a lot when I use the mouse. If I try using the trackpad then everything is fine. It gets really annoying when I'm fighting and my pointer skips powers and I click on the wrong powers. Anyone else have this problem or know how to fix it? Or need more info?